This article discusses how climate change may hamper response to flu. Mice exposed to heat wave temperatures ate less and showed weakened immune responses to the virus.
Previous studies have found that a warming climate may change the distribution of different diseases and the insects that carry them. Now, a new study in mice suggests that a warming climate may also hinder the immune response of animals and humans infected with viruses and other pathogens, researchers reported yesterday (February 4) in PNAS.
The researchers from the University of Tokyo subjected healthy female mice to cold (4 °C or 39.2 °F), room (22 °C or 71.6°F), or hot (36 °C or 96.8 °F) temperatures. Within 24 hours of living in high heat, mice ate less and lost 10 percent of their body weight. When exposed to a type of H1N1 influenza virus on day eight of the simulated heat wave, the animals’ immune systems had difficulty recognizing the virus and fighting it because of lagging responses from virus-specific killer T cells and antibodies.
But the researchers observed that the mice’s immune systems bounced back with a little help from supplemental nutrition in the form of glucose and short-chain fatty acids.
“People often lose their appetite when they feel sick. If someone stops eating long enough to develop a nutritional deficit, that may weaken the immune system and increase the likelihood of getting sick again,” study coauthor Takeshi Ichinohe says in a statement.